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To maintain coherence across the body, the circadian system must continuously align with environmental cues and internal signals, coordinating local cellular clocks and integrating tissue-specific rhythms into a unified temporal framework that governs physiology and behavior

38,39,40,41 Simultaneously, this metabolic alteration benefits T eff cells by reducing their reliance on oxygen for energy production, which enables them to maintain cytokine production and cytolytic activity even when they migrate into microenvironments within solid tumors that have low oxygen levels

[20] Still, it is a solid option for anyone who cannot tolerate retinol, is pregnant, or wants a daytime-compatible vitamin-A alternative

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