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For patients pursuing weight management or metabolic support with GLP-1 therapy, understanding supplement safety is essential

Ridker PM, Devalaraja M, Baeres FMM et al (2021) IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial

There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision

Since it's a once-weekly shot, many people find it easier to stick with no daily alarms or strict morning routines

Levels over .30 typically cause unconsciousness, and breathing can stop at .45