Emerging evidence for compromised axonal bioenergetics and axoglial metabolic coupling as drivers of neurodegeneration
Controlled uncoupling with modified dinitrophenol analogs (e.g., DNP-Mito) reduced mtROS by 65% while maintaining ATP synthesis in hypertensive rat models ( Experimental gene therapies delivering antioxidant enzyme genes (e.g., CAT, SOD, GPx) via viral vectors or nanoparticle carriers have shown promise in animal models by bolstering intrinsic defenses (Padmanaban et al., 2023)
Lim L, Jackson-Lewis V, Wong LC, Shui GH, Goh AX, Kesavapany S, et al
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Pyroptosis Pyroptosis is a lytic form of programmed cell death mediated by the gasdermin protein family [97] and plays a central role in host defense and inflammatory diseases [98]