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This can lead to: Increased oxidative stress and cellular damage Impaired liver function and detoxification Greater risk of lung inflammation and asthma development Weakened immune response , making it harder to fight off illness A major International Study of Asthma and Allergies in Childhood (ISAAC) involving over 322,000 children across 50 countries found a strong exposure-dependent relationship between acetaminophen use and the development of asthma, rhinoconjunctivitis, and eczema

[DOI] [PubMed] [Google Scholar] 44.Tanito M., Nishiyama A., Tanaka T., Masutani H., Nakamura H., Yodoi J., Ohira A

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Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks

Mhamdi et al., 2010b)