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(2018) enrolled 50 participants (22 patients with anxiety/depression and 28 healthy controls) and determined that patients with anxiety or depression exhibited significantly elevated plasma levels of LPS, zonulin, and fatty acid-binding protein 2 (FABP2), indicating intestinal barrier dysfunction and bacterial product translocation

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This dynamic release mechanism ensures antioxidant delivery occurs exclusively during oxidative surges, maintaining redox equilibrium without systemic interference