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In MetALD, the co-existence of metabolic risk factors (like obesity and T2DM) and moderate-to-high alcohol consumption creates a synergistic double-hit injury that accelerates disease progression and HCC risk significantly more than either factor alone

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Introduction Although bone mineral density (BMD) is normal or even elevated in individuals with type 2 diabetes mellitus (T2D), T2D has been associated with an increased fracture risk ( Glucagon-like peptide-1 receptor agonists (GLP-1 RA) and dipeptidyl peptidase 4 inhibitors (DPP-4i) were both introduced in Denmark in 2007, and new drugs in the classes are continually being introduced ( Knowledge about the impact of GLP-1 RAs on bone health and fracture risk is limited

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