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Another key limitation has to do with evaluation as methods are often tested on targets that have closely related complexes in the training data

Biochemistry , 3:895, 1964

Any perturbation of this balance, caused by excessive production of disulphide bonds during normal protein secretion or the production of mutant misfolded protein, might cause an excess of ROS to accumulate and ultimately lead to cell death

In item 2.2, we will discuss how OS is established in vitiligo patients and how they trigger the IS response to melanocytes

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