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La hiperglucemia crnica condiciona un microambiente entrico alterado, con incremento del estrs oxidativo, formacin de productos finales de la glucosilacin avanzada, inflamacin y reduccin de neurotransmisores y hormonas locales, afectando la vasculatura entrica y la celularidad del msculo liso19

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On the critical side: nausea in weeks 14 is the most common reason for early discontinuation, and some patients report that the weight loss plateau arrives around month 45 even on the full dose