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Interestingly, GSAAT(WT), GSAAT(C138S) and GSAAT(C396S) lines were still markedly redox responsive, and exhibited up to 20% higher enzyme activity when supplied with DTT relative to the UT control conditions, while the two gsa2 lines expressing GSAAT(C168S) and GSAAT(C190S) resulted only in 9% and 2% increased GSAAT activity upon addition of DTT to the extracts ( Supplementary Figure 3E )

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Additionally, transcriptional regulators may be beneficial in cell types that have nuclei and are associated with G6PD def related chronic disorders

If you want to understand more of the science of how glutathione works in your body, here are some good leads: Inflammation and glutathione Oxidation, aging and glutathione Infections and glutathione Mental health, depression and glutathione Digestion and glutathione Role of glutathione in cancer What makes a good glutathione supplement