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This phenomenon is mainly caused by the significant weight loss, including substantial fat loss in the face

Gut 52 : 370376 Schultz M et al

In 17,604 adults with overweight or obesity and established cardiovascular disease but no diabetes, semaglutide 2.4 mg cut the risk of major adverse cardiovascular events (heart attack, stroke, or cardiovascular death) by 20 percent over a mean follow-up of 39.8 months [9]

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Important SAEs to consider in participants both with and without T2D are the relatively rare events of acute cholecystitis and acute pancreatitis, which did not differ between groups