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Thymosin beta-4derived peptides such as TB-500 are widely investigated in wound-healing research because actin-mediated cellular migration is essential for epithelial repair, fibroblast movement, and structural reorganization of damaged tissue

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Our group also discovered the B7-1 and B7-2 molecules that bind to the costimulatory CD28 and coinhibitory CTLA-4 receptor and provide the critical costimulatory signal for full T cell activation, clonal expansion, and development of effector function through their interaction with CD28 on T cells