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However, researches on the underlying mechanisms are still limited

Tirzepatide dual-agonist mechanism (GIP + GLP-1) may provide stronger weight loss results on average compared to semaglutide single-agonist (GLP-1 only) approach

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They can recommend ways to manage these effects, such as: staying on the lower initiation dose for longer to let your body adjust taking an over-the-counter treatment for digestive problems adjusting your diet, exercise, sleep, or other lifestyle habits If even the lowest maintenance dosage of your GLP-1 medication feels too strong, your prescriber can recommend other, non-GLP-1 alternatives for your condition

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