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These factors extend the network of DAMPs signaling beyond the classical receptors and can further modulate immune cell responses in the postoperative period (for example, IL-33 can drive type 2 immunity and might aid in resolution of injury, whereas HMGB1 sustains inflammation and also promotes immunosuppression in late phases) (53)

Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols

One of these derivatives, deferiprone (3-hydroxy-1,2-dimethylpyridin-4(1 H )-one

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Furthermore, they will directly capture 1 O 2 and inhibit lipid peroxidation by trapping lipid alkoxy radicals (Sharma et al., 2012)