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The most frequently reported side effects include: Nausea (affecting approximately 1040% of patients, depending on the specific medication) Vomiting Diarrhoea Constipation Abdominal discomfort or bloating Reduced appetite These effects typically occur because GLP-1 medications slow gastric emptying and affect gut motility

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When initiating combination therapy, the choice between simultaneous initiation and sequential add-on therapy remains a clinical consideration

Glucagon-like peptide-1 (GLP-1) receptor analogs are drugs that mimic fullness hormone GLP-1 and have been shown to reduce appetite, slow digestion, help stabilize blood sugar levels and impact metabolism

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