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Although interventions such as glycemic and blood pressure control, reninangiotensinaldosterone system (RAAS) inhibitors, and sodiumglucose cotransporter 2 (SGLT2) inhibitors can partially slow disease progression, these therapeutic strategies remain limited, particularly in patients with impaired renal function or significant proteinuria, where reversing pathological alterations or fully restoring glomerular and tubular structure and function is challenging (Yu et al., 2024)

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He's technically still "in range" at all three ages, but he's lost 40% of his testosterone over four decades