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The metabolomic analysis was performed by following the Chemical Isotope Labeling (CIL) LC-MS protocol described in our previous report (81)

LoGuidice, A., Wallace, B

TLR9-targeted STAT3 silencing abrogates immunosuppressive activity of myeloid-derived suppressor cells from prostate cancer patients

Exclusionary criteria included any reported history of significant cardiorespiratory complications or recent lower extremity musculoskeletal injury that might limit high intensity exercise efforts