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In this context, several sensors and pathways regulating the transcription factors, such as activator protein 1 (AP-1), cAMP response element-binding protein (CREB), hypoxia inducible factor-1 (HIF-1), nuclear factor B (NF-B), activating transcription factor 4 (ATF-4), and nuclear factor-erythroid 2-related factor-2 (Nrf2), have been described (Marinho et al

Additionally, the -oxidation of FFAs is suppressed in states of insulin resistance, thereby further promoting the accumulation of hepatic lipids ( 2.2 Lipid metabolism disorder The liver plays a distinctive role in lipid metabolism, acting as a site for lipid uptake, synthesis, oxidation, and distribution of lipids to peripheral tissues ( Dysregulation of DNL is a central feature of liver lipid accumulation in NAFLD patients (Sanders and Griffin, 2016)

During your period (the menstrual phase), your estrogen and progesterone levels are at their lowest point

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PMID: 8688086 Kojima M, et al