In principle, this may be analogous to the demonstrated BPC 157NO-system relations in many models and species (see Sikiric et al., 2014
1 It can also be found in small amounts in certain foods like beef, fish, and chicken
Specific examples of methylation in detoxification: Arsenic detoxification requires sequential methylation: arsenite to monomethylarsonic acid to dimethylarsinic acid (the excretable form), catalyzed by arsenic methyltransferase (AS3MT) using SAM-e R Mercury undergoes methylation by gut bacteria, converting inorganic mercury to more toxic methylmercury (this is detrimental methylation, not detoxification) R COMT methylation of 4-hydroxy catechol estrogens prevents them from forming reactive quinones that generate ROS and DNA damage R 6
2,13 Liver biopsy is the only test that distinguishes hepatic steatosis from nonalcoholic steatohepatitis, but its routine use is controversial in persons with nonalcoholic fatty liver disease
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