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Higher CD38 activity contributes to age-related NAD+ decline

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This may be appealing for patients who dislike needles, feel anxious about injections, travel frequently, or want a medication routine that feels similar to taking a daily supplement or tablet

Likewise, copper is the cofactor of metabolic enzymes (e.g., cytochrome c oxidase in mitochondria, CuZnSOD in cytosol) and it catalyzes the enzymatic activity of key enzymes of the secretory pathway (reviewed in Polishchuk and Lutsenko, 2013