In a small study, blood catalase and GSH/GSSG levels significantly increased after administration of 6000mg NAC for 6 weeks in patients with Parkinsons disease and 3 healthy participants
It will often not happen on the first GSH (it can of course) but if there are methyl cycle slow downs and then yOu supply the B Vit cofactors and a methyl donor suddenly the methyl cycle donates more and more to the HCYS-Cystathionine pathway (which primes sulfite formation and SUOX) and THEN you give GSH which also donates to the same pathway A sulfite reaction can look like anaphylaxis and can have hive reactions and all you mention

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Signal Transduct Target Ther 7(1):378 Walshe JM (2007) Wilsons disease
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