By participating in NLRP3 and NF-kB related signalling pathways, empagliflozin, a new hypoglycaemic drug that can improve the prognosis of CVDs, can attenuate ferroptosis, fibrosis, apoptosis, and inflammation in doxorubicin-treated mice and significantly improve cardiac function, thereby opening up a new avenue for the treatment of doxorubicin-related cardiotoxicity [150, 151]
50,51 Moreover, GIP infusion significantly reduced CTX-I levels in healthy humans, 52 as well as in T1D or T2D, 53 indicating a robust suppression of bone resorption in various settings that is independent of the established effects of GIP on insulin secretion
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These may include: Nausea, vomiting or diarrhoea (most common early on) Constipation Fatigue Mild increases in heart rate (similar to changes seen with GLP-1 medicines) Side effects were more frequent at higher doses (8 mg and 12 mg), but still rated mild to moderate overall
The next decade will be defined by the connection between access, science, and confidence, he says
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