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Availability of Data and Material Not applicable Ethics Approval Not applicable Consent to Participate Not applicable Consent for Publication Not applicable Author Contributions All authors (F.P, S.M.O, J.M, F.C.S) meet ICMJE authorship criteria, made substantial contributions to the conception and design of the work and to drafting or critically revising the manuscript, approved the final version, and agree to be accountable for all aspects of the work

The probe used consisted of a human influenza hemagglutinin (HA) tag linked to Ub, the C -terminal of which was modified with a terminal alkene

Laboratory protocol development for FOXO4-DRI research requires careful consideration of dosing strategies, administration timing, and experimental endpoints to maximize scientific insights while ensuring reproducible results

Squalane : Squalane is a lightweight, non-comedogenic oil that moisturizes and protects the skin