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L-Glutathione is also an inhibitor of the Tyrosinase enzyme (the pigment-producing enzyme), causing less production of melanin (pigmentation pigments) and increasing the production of Pheomelanin (light pink pigments) that makes skin look brighter with reduction of dark circles

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o Viking Therapeutics, Inc

After TBI, the NAD-dependent deacetylase sirtuin-1 (Sirt1) that promotes Nrf2 is downregulated, reducing Nrf2 signaling and Nrf2-induced transcription of antioxidant, antiapoptotic and metabolic genes [80]

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