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50,88,89 Inhibition of notch signaling can promote glucose uptake in muscle thus improving glucose tolerance 90 (Fig

193 There is also evidence that physical activity and nutrition have preventive effects and metabolic improvement independent of body weight

Cell Death Differ 8:11311133 Ribeil JA, Zermati Y, Vandekerckhove J et al (2007) Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1

Gluckman PD, Hanson MA, Cooper C, Kent L

Many therapies now considered foundational in perioperative medicine were initially adopted based on mechanistic plausibility and early observational signals before high-quality surgical outcome trials were performed