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The safest protocol is to discontinue phentermine under medical supervisiontypically over 1-2 weeksand then initiate semaglutide after a wash-out period

What's more, the burning of fatty acids, which saves glycogen stores, will provide energy over time

10.1074/jbc.M211596200

Other considerations include if this class of medications is dropped from coverage, patients on the drugs will need to find other ways to pay for it if they want to continue, the affordability and availability of the medications, and what will the long-term impact be if patients stop taking the medications suddenly