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The clustering between specific biological and clinical features has been postulated to identify a theoretical dimension labelled immuno-metabolic depression (IMD) [2] (aligning with the Research Domain Criteria (RDoC) framework [52]

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Consistent with perturbed glutathione metabolism, CLP mice exhibited significant downregulation of the Nrf2/HO-1 antioxidant axis: reduced Nrf2, a master transcriptional regulator of antioxidant genes, and its target HO-1 were reduced, indicating impaired upstream antioxidant regulation

Due to its antioxidant properties, curcumin can potentially serve as a food preservative (162)

Also, it was seen that HGH given cyclically achieved statistically significant increases in BMD of the lumbar spine and of some areas of the hip in postmenopausal women