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Nausea affects approximately 44% of participants in pooled STEP trial data, with diarrhea (30%), vomiting (24%), and constipation (24%) also common

There are clinical trials and there are anecdotal reports, but they are not substantial

(2) ROS activates NF-B and MAPK signaling pathways, upregulating the expression of MMPs (MMP-13, MMP-3) and inflammatory factors (IL-1, TNF- ), thereby accelerating the degradation of type II collagen (Col-II) and proteoglycans

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Specifically, elevated S100B protein levels strongly correlate with injury severity (Azar et al., 2017), poor clinical outcomes (Kleindienst et al., 2010), and higher mortality rates (Pfortmueller et al., 2016) in TBI cases