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Haematologica 102 , e285e288 (2017)

Reconstitution, per-injection dosing, and why KPV makes this more than Glow

Histone acetylation by histone acetyltransferases (HATs) is likely to activate transcription by relaxing chromatin and histone deacetylation by histone deacetylases (HDACs) is likely to inhibit transcription by compacting chromatin (90)

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Therefore, we assumed that the disappearance of GLA protein in Clone #5 was due to the early stop codon and that the minimal mRNA expression in Clone #9 resulted in a low amount of GLA protein (Fig