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Generally, herbal medicines are tolerated satisfactorily, having few mild or moderate adverse effects when used appropriately, but few herbal medicines have undergone randomized clinical trials to determine their safety and quality, and most of the reported clinical studies results were not significative due to methodological flaws that made the data of dubious value (duration, use of the blinding, sample size, subject selection, controls adequacy, mode of treatment, use of quantitative outcome measures, and results reports) (Gagnier et al., 2006)

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