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Gizmodo: Why have doctors and agencies like the FDA been worried about this possible risk of thyroid cancer from using GLP-1s

At tissue level, RAS (renin-angiotensin system) can be upregulated with non-hemodynamic effects ( Several studies reported that inappropriate ANGII/AT1R activation occurs because of different mechanisms, particularly in patients with T2DM

Clinical trials show that Ozempic is less effective than Wegovy in promoting weight loss, because it is used at lower doses

But it may be detrimental for killing cancer cells.[ref] COVID-19 : GABA may also help to limit an overactive immune response in severe COVID-19

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