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Within days to weeks of stopping treatment, patients generally experience return of appetite to pre-treatment levels, faster gastric emptying, and loss of the medication's effects on satiety signaling

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[14] [15] For those with specific athletic goals, sports nutrition consensus statements (including those from the International Olympic Committee and the British Dietetic Association's Sports Dietitians group) suggest protein intakes in the range of 1.62.2 g per kg of body weight per day to support muscle retention during periods of energy restriction

These differences matter clinically: larger average weight loss translates into bigger improvements in blood pressure, glycemic measures, sleep apnea metrics, mobility, and quality of life for many patients