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Literature on this topic is too large to summarise comprehensively, but it suffices to say that GLP1R agonists are capable of increasing the activity of neurons that promote satiety, while simultaneously decreasing the activity of neurons that promote hunger

Future multicenter double-blind, randomized, placebo-controlled trials in a large and homogeneous sample of patients should focus on higher doses and more prolonged treatment

Triglyceride improvements typically become measurable within 48 weeks of starting semaglutide, with maximal benefit usually seen after 1216 weeks as weight loss accumulates

10.1016/j.jep.2021.113789 131 LiuW.WangX.ChenY.ZhangH.ChenJ.ZhangJ.et al (2022a)

Supports healthy methylation pathways