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TGF-1 could also induce adult mouse hepatocytes to undergo EMT, and up to 45% of the FSP1-postive fibroblasts are derived from hepatocytes in carbon tetrachloride (CCL4)-induced fibrotic liver (94)

Hypertension and metabolic syndrome together lead to more cases of left ventricular hypertrophy, microalbuminuria, increased intima-media thickness, and hypertensive retinopathy (115)

Faivre, A

Together, these findings underscore that the cGASSTING pathway is not only a molecular sentinel for pathogen detection but also a critical driver linking mitochondrial stress and mtDNA release to chronic neuroinflammation in NDDs

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