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Other groups have reported increased efficacy with 5FU and metformin in models of acquired resistance 53,54,55,56 , in spheroid culture 53 or xenograft/PDX models 57,58,59 , but the potential of combined 5FUCI inhibitor co-treatment in a chemo-naive, immune-competent setting requires further investigation

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weeks 812 show significant improvements in firmness, wrinkle depth, and collagen density

The number of independent biological samples per group is indicated in the figure legends and the Source Data files