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In skeletal muscle, augmented NO signaling has been demonstrated to enhance the delivery of nutrients, promote mitochondrial biogenesis, and facilitate glucose uptake, thereby contributing to improved muscle oxygenation and endurance (28)

Additionally, engaging in regular physical activity in the form of aerobic exercises and strength training can increase your metabolic rate and promote fat loss

Mechanistic sub-study embedded in an efficacy trial + Incorporate GSM/dryness endpoints (validated questionnaires, clinician assessment, pH) into semaglutide RCTs or pragmatic trials, with pre-specified subgroup analyses by menopausal status and HRT use

inhibiting this pathway can reduce insulin oversecretion and prevent compensatory insulin resistance caused by persistently high insulin levels in -cells (51, 52)

Energy intake patterns stabilize and metabolic fat-adaptation begins