A wave of 2nd generation GLP-1 agonists came to market between 2014-2021, improving clinical outcomes and providing more convenient dosing and administration options
GSH, LS, GSH-NPs, and LS-NPs demonstrated minimal enhancement of tubular cells, with partial restoration of renal tubule morphology and reduced protein fluid accumulation within the lumen
In a clinical study, neuropsychological deficiencies, including reduced intelligence quotient, impaired fine-motor function, social skill deficits, and decreased olfaction, were observed in patients with BBS (10)
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But this does not mean every patient should interpret GLP-1 therapy the same way