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In addition, the applicant submitted 32 supplemental background articles describing topics including general disease processes and disease prevalence
Cis increases ACSL4 expression while suppressing GPX4 expression and promotes mitochondrial dysfunction through excessive ROS production (Zhang S
These metabolites included a range of intermediates from the central carbon metabolism including tricarboxylic acid (TCA) cycle intermediates, amino acids, saturated fatty acids, and unsaturated fatty acids
In terms of sex, female mice were shown to be less susceptible to APAP toxicity [165167]
More specifically, oral administration is safer than intramuscular injection in animal models because artemisinin is present in experimental animals for a long period after its slow release from intramuscular formulations, leading to severe side effects (Gordi and Lepist, 2004)
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