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Key Takeaways Weight loss peptides: GLP-1 is a naturally occurring peptide hormone that slows digestion and regulates appetite, making it an effective tool for managing weight

This is the primary safety metric for the insulin resistance concern

GLP-1 medications reduce appetite and slow gastric emptying, which often creates a significant calorie deficit in the early weeks of treatment

According to a 2023 editorial in The Lancet Diabetes & Endocrinology , the glucagon component requires careful monitoring for its effects on hepatic glucose output, particularly in patients with diabetes

A 2025 study in the Personalised Medicine journal confirms it