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Ohayon MM, Chen MC, Bixler E, et al

In the SURMOUNT-1 trial, patients taking the highest dose achieved up to 22.5% average body weight reduction over 72 weeks

Almost 40% of patients taking second-line diabetes drugs stop treatment, but this number is even higher (50%) among those taking GLP-1s

If its cloudy, it could be a sign of contamination or peptide degradation

130 With this varied evidence, metformin has shown its antiproliferative activity in the cancer cell lines which can prove instrumental in cancer management but the concentration at which these effects are demonstrated are quite high as compared to the therapeutic levels in plasma and can prove toxic for humans so studies with improved protocols with lower concentration need to be tested in future to establish its effective anticancer property in clinical subjects