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meanwhile, it regulates the expression of key glycolytic enzymes (e.g., HK2) to drive metabolic reprogramming ( 4.2 Emphysema Emphysema represents another critical pathological hallmark of COPD, defined as abnormal permanent enlargement of the airspaces distal to the terminal bronchioles, accompanied by destruction of alveolar walls and without significant fibrosis. Clinically, two primary subtypes predominate: centrilobular emphysema and panlobular emphysema

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The redacted study protocols and statistical analysis plan are provided as part of the manuscript files

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3c, two ABX-SDV mice were excluded due to weakness or death after surgery