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High uric acid promotes dysfunction in pancreatic cells by blocking IRS2/AKT signalling

Moreover, the content of GSH in some tumor cells is typically associated with higher levels of GSH-related enzymes, such as -glutamylcysteine ligase (GCL) and -glutamyl-transpeptidase (GGT) activities, as well as a higher expression of GSH-transporting export pumps [11, 12]

This stress occurs when there is an imbalance between free radicals (unstable molecules) and the antioxidants needed to neutralize them

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Mol Biol Rep 47:20232034 etin A, ifti O, Otlu A (2016) Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats