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As illustrated in Figure 1, adipocyte-derived leptin signals peripheral energy status to the arcuate nucleus (ARC) of the hypothalamus

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A 2026 review describes GLP-1 signalling influencing keratinocyte function, immune cell activity and wound healing, and modulating pathways including cAMP/PKA, AMPK, PI3K/Akt and NF-kappaB as well as the IL-23/Th17/IL-17 axis

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Weight loss injections like semaglutide (Wegovy), liraglutide (Saxenda), and tirzepatide (Zepbound) are FDA-approved medications for obesity treatment