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Whilst mTORC1 activates S6 kinase, which phosphorylates serine residues on IRS which in turn uncouples IRS from the receptor and its substrates, mTORC2 can reactivate this signalling

ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies

Positive changes in body composition

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0.5mg 1mg 2mg 4x/week 4 injections/week P/T Ratio: ~1.8 Peak Reduction: 30% 6