biology of incretins glp 1 and gip GLP‐1, the two incretin hormones: Similarities and differences Role of endogenous incretin hormones,

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Strong preclinical coverage: improved insulin sensitivity in aged and high-fat-fed mice (Lee et al., Cell Metabolism 2015) and roughly doubled treadmill running time in old mice (Reynolds et al., Nature Communications 2021)

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Activation of Notch signaling and the expression of its downstream target gene, hairy and enhancer of split 1 ( Hes1 ) in TA cells repress the expression of transcription factors crucial for entry into the secretory lineage including atonal homolog 1 ( Atoh1 ) and induce absorptive cell fate commitment

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