Beyond that, the supplements guide for GLP-1 users recommends considering: Electrolytes: Especially during the first few weeks when GI side effects are most prevalent B12: Often combined with GLP-1 agonists in compounded formulations, as semaglutide with B12 and tirzepatide with B12 combinations demonstrate Fiber: To support digestive regularity, which can be disrupted by altered gastric motility Biotin: Particularly if hair thinning occurs, as a preventive measure alongside adequate protein Exercise during retatrutide use Resistance training is more important than cardio during a GLP-1 protocol
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Generally, it is recommended to administer Semaglutide GLP-1 once a week, on the same day each week, and it can be taken at any time, with or without food
Injectable GLP-1 Medications: Injectable semaglutide and tirzepatide are administered once weekly via subcutaneous injection according to prescribing information and clinician guidance
Most patients begin noticing appetite suppression and reduced hunger within the first 12 weeks of starting GLP-1 therapy
