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GLP-1 medications have been shown to promote weight loss and support healthier body composition
It has been suggested that hyperthyroidism acts as a hormonal trigger for the activation of nuclear factor kappa, transcription factor involved in the regulation of pro-inflammatory cytokines TNF- and IL-6 85,86
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For the first half of the trial (26 weeks), the volunteers were divided into four groups: one group only given semaglutide, two groups given semaglutide and a lower or higher dose of trevogrumab, and a fourth given all three drugs at once
Based on the Wegovy and Mounjaro timelines, MHRA approval is plausible in late 2027 to mid 2028, with NICE recommendation following 6 to 18 months later
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