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Activation of GABA A receptor leads to an influx of chloride ions, which inhibits the propagation of action potential

Whether ferroptosis or other forms of PCD can be clearly distinguished during the disease for targeted prevention and treatment is also deserves further exploration

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The interplay between CoQ redox balance, AMPK activation and ETC directionality suggests that the ferroptotic outcome of complex I inhibition depends not only on its biochemical activity but also on the metabolic state of the cell

Here, Ekihiro Seki & team implicate the fungal sensing adaptor protein CARD9 in maintaining gut barrier integrity under metabolic stress, finding that the loss of fungal sensing exacerbates liver injury in a murine model of MASLD