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Natural IGF-1 has a very short half-life usually less than 20 minutes before your body clears it out

The activation of GIP receptors by retatrutide promotes glucose dependent insulinotropic polypeptide insulin secretion and insulin release in response to food intake, significantly improving glycemic control

Combined with rising hunger signals, these shifts can quietly contribute to weight returning after stopping GLP-1s

Understanding these relationships allows researchers to optimize protocols for their specific administration constraints, subject size, and dosing frequency

Lifestyle drift and metabolic adaptation also contribute to weight gain during treatment