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Toxicological findings consistently indicate size- and shape-dependent uptake and effects: smaller particles exhibit greater cellular internalisation, reactivity, and biodistribution, with predominant oxidative, inflammatory, metabolic, and genotoxic responses, whereas larger microplastics more often provoke mechanical irritation

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For accurate determination of insulin secretion, independent of varying hepatic insulin extraction, it may be useful to measure plasma levels of C-peptide, proinsulin's connecting peptide, which is not extracted in the human liver

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