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[11] [12] Additionally, high doses can cause gastrointestinal side effects including nausea, diarrhoea, and abdominal discomfort

Intestinal alkaline phosphatase (ALPI, Figure 2) plays an essential role in the absorption of dietary B vitamins including thiamine (100)

At the same time cardiovascular deaths and disease evolution have increased at an astonishingly fast rate in low- and middle-income countries due to the increase in obesity, sedentary lifestyles and unhealthy habits[262]

This is the medication doing exactly what it should at this phase of treatment